Iridoid and Aromatic Glycosides from Scrophularia ningpoensisHemsl. and Their Inhibition of [Ca2+]i Increase Induced by KCl
✍ Scribed by Bin Chen; Yan Liu; Hong-Wei Liu; Nai-Li Wang; Bao-Feng Yang; Xin-Sheng Yao
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 287 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1612-1872
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Bioassay‐guided fractionation of EtOH extract of the roots of Scrophularia ningpoensis Hemsl. resulted in the isolation of three new iridoid glycosides, i.e., 6″‐O‐caffeoylharpagide (1), 6″‐O‐feruloylharpagide (2), and 6″‐O‐β‐glucopyranosylharpagoside (3), and five new aromatic glycosides, i.e., 2‐(3‐hydroxy‐4‐methoxyphenyl)ethyl O‐α‐arabinopyranosyl‐(1→6)‐O‐α‐rhamnopyranosyl‐(1→3)‐O‐β‐glucopyranoside (4), phenyl O‐β‐xylopyranosyl‐(1→6)‐O‐β‐glucopyranoside (5), 3‐methylphenyl O‐β‐xylopyranosyl‐(1→6)‐O‐β‐glucopyranoside (6), 6‐O‐cinnamoyl β‐fructofuranosyl‐(2→1)‐O‐α‐glucopyranosyl‐(6→1)‐O‐α‐glucopyranoside (7), and 6‐O‐feruloyl β‐fructofuranosyl‐(2→1)‐O‐α‐glucopyranosyl‐(6→1)‐O‐α‐glucopyranoside (8), together with four known compounds, i.e., 6″‐O‐α‐D‐galactopyranosyl harpagoside (9), 6″‐O‐(p‐coumaroyl) harpagide (10), harpagoside (11), and angoroside C (12). Activity of the isolated compounds on [Ca^2+^]~i~ increase induced by KCl was evaluated on rat cardiac myocytes using confocal laser scanning microscopy. Iridoid glycosides 1, 10, and 11, and aromatic glycosides 5 and 6 significantly inhibited the increase of [Ca^2+^]~i~ induced by KCl at 100 μM.