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C9-Iridoids from Scrophularia buergeriana

✍ Scribed by Shuang-Jun Lin; Chang-Heng Tan; Shan-Hao Jiang; Yi-Ming Li; Da-Yuan Zhu


Publisher
John Wiley and Sons
Year
2007
Weight
16 KB
Volume
38
Category
Article
ISSN
0931-7597

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C9-Iridoids from Scrophularia buergerian
✍ Shuang-Jun Lin; Chang-Heng Tan; Shan-Hao Jiang; Yi-Ming Li; Da-Yuan Zhu 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 68 KB

Four new iridoids, buergerinins B -E (1 -4), along with three known iridoids, were isolated from the roots of Scrophularia buergeriana. Their structures were identified on the basis of spectroscopic analysis.

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## Abstract In previous work, we isolated 7 neuroprotective iridoid glycosides from the 90% MeOH fraction of __Scrophularia buergeriana__ (Scrophulariaceae). We therefore investigated the mode of action of 8‐__O‐E‐p__‐methoxycinnamoyl‐harpagide (8‐MCA‐Harp), the most potent neuroprotective iridoid,

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## Abstract Bioassay‐guided fractionation of EtOH extract of the roots of __Scrophularia ningpoensis__ Hemsl. resulted in the isolation of three new iridoid glycosides, __i.e.__, 6″‐__O__‐caffeoylharpagide (**1**), 6″‐__O__‐feruloylharpagide (**2**), and 6″‐__O__‐__β__‐glucopyranosylharpagoside (**