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C677T mutation in the 5,10-MTHFR gene and risk of Down syndrome in Italy

✍ Scribed by Stuppia, Liborio; Gatta, Valentina; Gaspari, Anna Rita; Antonucci, Ivana; Morizio, Elisena; Calabrese, Giuseppe; Palka, Giandomenico


Book ID
110025240
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
57 KB
Volume
10
Category
Article
ISSN
1018-4813

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Evaluation of C677T and A1298C polymorph
✍ Ana Paula Carneiro Brandalize; Eliane Bandinelli; Pollyanna Almeida dos Santos; πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 119 KB πŸ‘ 1 views

## Abstract Abnormal folate/homocysteine metabolism due to polymorphisms in genes involved in this pathway has been implicated as an etiologic factor in Down syndrome (DS). This case–control study aimed to evaluate the effect of maternal C677T and A1298C polymorphisms of the methylenetetrahydrofola