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C1-Methylated 5-hydroxy-2-(dipropylamino)tetralins: central dopamine-receptor stimulating activity

✍ Scribed by Hacksell, Uli; Johansson, Anette M.; Arvidsson, Lars Erik; Nilsson, J. Lars G.; Hjorth, Stephan; Carlsson, Arvid; Wikstroem, Hakan; Sanchez, Domingo; Lindberg, Per

Book ID: 126995347
Publisher: American Chemical Society
Year: 1984
Tongue: English
Weight: 736 KB
Volume: 27
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00374a012

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## Abstract The title compounds were synthesised in 7 steps from 1,7‐dihydroxynaphthalene as follows: 1,7‐dihydroxynaphthalene was methylated and subjected to a Birch reduction to yield 8‐methoxy‐2‐tetralone. Reductive amination with sodium cyanoboro[^3^H]hydride and n‐propylamine gave 8‐methoxy‐2‐