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C-terminal neurofilament phosphorylation fosters neurofilament–neurofilament associations that compete with axonal transport

✍ Scribed by Sangmook Lee; Neethu Sunil; Thomas B. Shea

Book ID
102098182
Publisher
Wiley (John Wiley & Sons)
Year
2010
Tongue
English
Weight
428 KB
Volume
68
Category
Article
ISSN
1949-3584

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## Abstract Cyclin‐dependent kinase 5 (cdk5) phosphorylates the high molecular weight neurofilament (NF) protein. Overexpression of cdk5 inhibits NF axonal transport and induces perikaryal accumulation of disordered phospho‐NF cables. Experimental and clinical motor neuron disease is characterized