Axonal transport of neurofilament (NFs) is considered to be regulated by phosphorylation. While existing evidence for this hypothesis is compelling, supportive studies have been largely restricted to correlative evidence and/or experimental systems involving mutants. We tested this hypothesis in ret
β¦ LIBER β¦
Does neurofilament phosphorylation regulate axonal transport?
β Scribed by Thomas B Shea; Cheolwha Jung; Harish C Pant
- Book ID
- 117343928
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 186 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0166-2236
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## Abstract Cyclinβdependent kinase 5 (cdk5) phosphorylates the high molecular weight neurofilament (NF) protein. Overexpression of cdk5 inhibits NF axonal transport and induces perikaryal accumulation of disordered phosphoβNF cables. Experimental and clinical motor neuron disease is characterized