c-myc oncogene expression and cell proliferation in mixed oligo-astrocytoma

✍ Scribed by Moinak Banerjee; Amit K. Dinda; Subrata Sinha; Chitra Sarkar; Meera Mathur

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 438 KB
• Volume: 65
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19960315)65:6<730::aid-ijc3>3.0.co;2-#

✦ Synopsis

Mixed gliomas (oligo-astrocytomas) are brain tumours with an admixture of 2 different cell populations: astrocytes and oligodendroglia. On the basis of histological features and behaviour, these tumours are classified as low-grade mixed gliomas (MG) and malignant mixed gliomas (MMG). We have studied the relationship between c-myc protein expression and cellular proliferation in this class of tumours. Using antibody c-33 for c-myc and PC-I0 for the proliferating cell nuclear antigen (PCNA), immunohistochemistry was performed on 14 MG and 9 MMG. PCNAwas increased in MMG as compared to MG in both astrocytic and oligodendroglial areas. However, more c-mycpositive cells were seen only in the astrocytic areas of MMG. Analysis of the relationship of c-rnyc and PCNA suggests that the correlation of c-myc with cellular proliferation is dependent on tissue type and differentiation status.