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Expression of cellular oncogenes in human gastric carcinoma: c-myc, c–erb B2′ and c-Ha-ras

✍ Scribed by Dr. Young-Jin Kim; Hoi–dong Ghu; Dong-Yi Kim; Hyun-Jong Kim; Shin-Kon Kim; Chang-soo Park

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
333 KB
Volume
54
Category
Article
ISSN
0022-4790

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✦ Synopsis

Expression of oncogenes in gastric cancer tissue was evaluated with immunohistochemical staining methods using monoclonal antibodies to products of the oncogenes. Rates of expression in gastric cancer tissue were 50% for c-myc, 72% for c-erb B,, and 56% for c-Ha-rus oncogenes. Expression of these oncogenes in gastric cancer was not correlated with the histologic differentiation. The c-Ha-rus oncogene was positive in 19 of 26 cases with lymph node and/or distant metastasis: the positive rate was significantly higher than in cases without metastasis. Results suggest that c-Ha-rus oncogene is related to the prognosis of gastric cancer. The rate of expression of c-myc and c-Ha-rus oncogenes in gastric cancer tissues was higher in the DNA aneuploid group than in the DNA diploid group. Expression of c-myc and c-Ha-rus oncogenes correlated with other prognostic factors such as DNA ploidy pattern and metastasis. These oncogenes can be used to evaluate prognosis of gastric cancer patients.

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