C-Glucuronides, a Novel Type of Drug Metabolites
โ Scribed by Wilhelm J. Richter; Karl O. Alt; Walter Dieterle; Johann W. Faigle; Hans-Peter Kriemler; Hans Mory; Tammo Winkler
- Book ID
- 102856477
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- German
- Weight
- 985 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0018-019X
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โฆ Synopsis
Abstract
The structure elucidation of Cโฮฒโglucuronides of sulfinpyrazone (Anturan^ยฎ^) and phenylbutazone (Butazolidin^ยฎ^) by spectroscopic means is reported. These conjugates represent a novel type of drug metabolites.
๐ SIMILAR VOLUMES
A method for the assay of glucuronidation of C- and N-hydroxylated metabolites of the carcinogen N-2-fluorenylacetamide is described. The method employs UDP-[U-14C ))glucuronic acid and Baker C18 extraction columns for separation of the glucuronides from their aglycones and from the glucuronic acid.