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Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites

โœ Scribed by Thomas G. Hammond; Sophie L. Regan; Xiaoli Meng; James L. Maggs; Rosalind E. Jenkins; Gerry L. Kenna; Jean G. Sathish; Dominic P. Williams; B. Kevin Park


Book ID
108287686
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
325 KB
Volume
278
Category
Article
ISSN
0300-483X

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Pharmacokinetics of naproxen, its metabo
โœ Tom B. Vree; Magdalena Van Den Biggelaar-Martea; Corrien P. W. G. M. Verwey-Van ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 558 KB

The aim of this investigation was to assess the pharmacokinetics of naproxen in 10 human subjects after an oral dose of 500 mg using a direct HPLC analysis of the acyl glucuronide conjugates of naproxen and its metabolite O-desmethylnaproxen. The mean t , of naproxen in 9 subjects was 24'756.4 h (ra