Pharmacokinetics of naproxen, its metabo
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Tom B. Vree; Magdalena Van Den Biggelaar-Martea; Corrien P. W. G. M. Verwey-Van
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Article
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1993
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John Wiley and Sons
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English
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The aim of this investigation was to assess the pharmacokinetics of naproxen in 10 human subjects after an oral dose of 500 mg using a direct HPLC analysis of the acyl glucuronide conjugates of naproxen and its metabolite O-desmethylnaproxen. The mean t , of naproxen in 9 subjects was 24'756.4 h (ra