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The pharmacokinetics of naproxen, its metabolite O-desmethylnaproxen, and their acyl glucuronides in humans. Effect of cimetidine.

✍ Scribed by TB Vree; M Van den Biggelaar-Martea; CP Verwey-Van Wissen; ML Vree; PJ Guelen


Book ID
117945471
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
897 KB
Volume
35
Category
Article
ISSN
0306-5251

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πŸ“œ SIMILAR VOLUMES


Pharmacokinetics of naproxen, its metabo
✍ Tom B. Vree; Magdalena Van Den Biggelaar-Martea; Corrien P. W. G. M. Verwey-Van πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 558 KB

The aim of this investigation was to assess the pharmacokinetics of naproxen in 10 human subjects after an oral dose of 500 mg using a direct HPLC analysis of the acyl glucuronide conjugates of naproxen and its metabolite O-desmethylnaproxen. The mean t , of naproxen in 9 subjects was 24'756.4 h (ra