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Determination of Naproxen and its Metabolite, 6‐O‐Desmethylnaproxen, in Human Urine by Capillary Isotachophoresis

✍ Scribed by Sádecká, Jana; Netriová, Jana

Book ID
126739929
Publisher
Taylor and Francis Group
Year
2005
Tongue
English
Weight
99 KB
Volume
28
Category
Article
ISSN
1082-6076

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Pharmacokinetics of naproxen, its metabo
Pharmacokinetics of naproxen, its metabolite O-desmethylnaproxen, and their acyl glucuronides in humans
✍ Tom B. Vree; Magdalena Van Den Biggelaar-Martea; Corrien P. W. G. M. Verwey-Van 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 558 KB

The aim of this investigation was to assess the pharmacokinetics of naproxen in 10 human subjects after an oral dose of 500 mg using a direct HPLC analysis of the acyl glucuronide conjugates of naproxen and its metabolite O-desmethylnaproxen. The mean t , of naproxen in 9 subjects was 24'756.4 h (ra