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Budd–Chiari syndrome in a paroxysmal nocturnal hemoglobinuria patient with coexistence of factor II and MTHFR mutations

✍ Scribed by A. I. SHAMSEDDINE; Z. K. OTROCK; R. A. R. MAHFOUZ; J. A. MAKAREM; A. T. TAHER


Book ID
109148938
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
72 KB
Volume
3
Category
Article
ISSN
1538-7933

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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hemolytic anemia caused by somatic mutations in the phosphatidylinositol glycan-complementation class A gene and the resulting absence of a key complement regulatory protein, CD59. Affected red blood cells in patients with PNH undergo int