Role of Btk in B cell development and si
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Stephen Desiderio
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Article
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1997
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Elsevier Science
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English
β 669 KB
Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal