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Btk function in B cell development and response

✍ Scribed by Anne B Satterthwaite; Zuomei Li; Owen N Witte


Book ID
115647922
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
97 KB
Volume
10
Category
Article
ISSN
1044-5323

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Role of Btk in B cell development and si
✍ Stephen Desiderio πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 669 KB

Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal