Bromination of N,N'-Substituted Malonodiamides
β Scribed by V. A. Georiyants; P. A. Bezuglyi
- Book ID
- 110402514
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 2002
- Tongue
- English
- Weight
- 38 KB
- Volume
- 38
- Category
- Article
- ISSN
- 1070-4280
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π SIMILAR VOLUMES
Regioselective halogenation of the N-susbtituted lactams (3a)-(3d) affords the corresponding exocyclic bromides (4a)-(4d). The procedure provides a novel alternative mute to N-(c&aloaJkyl)-substituted lactams, which are of particular interest in the synthesis of g-lactam antibiotics. Reactions of N
## Abstract Reaction of __N__^1^βsubstituted uracils with bromine in water at pH 7 leads to 5βbromoβ6βhydroxyβ5,6βdihydrouracils. For different __N__^1^βsubstituents these products were isolated and the relatively stable derivatives were characterized by ^1^H NMR and mass spectroscopy. On electroph