Regioselective halogenation of the N-susbtituted lactams (3a)-(3d) affords the corresponding exocyclic bromides (4a)-(4d). The procedure provides a novel alternative mute to N-(c&aloaJkyl)-substituted lactams, which are of particular interest in the synthesis of g-lactam antibiotics. Reactions of N
✦ LIBER ✦
Bromination of N,N′-Substituted Malonodiamides.
✍ Scribed by V. A. Georiyants; P. A. Bezuglyi
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 100 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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