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Bromination of methyl substituted 1,2,5-thiadiazoles with N-bromosuccinimide

✍ Scribed by Shuntaro Mataka; Masayoshi Kurisu; Kazufumi Takahashi; And Masashi Tashiro


Book ID
112127564
Publisher
Journal of Heterocyclic Chemistry
Year
1984
Tongue
English
Weight
239 KB
Volume
21
Category
Article
ISSN
0022-152X

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Selective Bromination of 4,5-Dimethylthi
✍ Mouaffak Al Hariri; Olivier Galley; FΓ©lix Pautet; Houda Fillion πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 313 KB

Radical bromination of 4,5-dimethylthiazole (1) was carried out using different stoichiometries of N-bromosuccinimide in the presence of 2,2Ј-azobisisobutyronitrile. Mono-, tri-and tetrabromo compounds 2, 5, and 6 were obtained in good yields with regioselectivity while the dibromo derivatives 3 and