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Breast cancer risk associated with proliferative breast disease and atypical hyperplasia

✍ Scribed by William D. Dupont; Fritz F. Parl; William H. Hartmann; Louise A. Brinton; Alan C. Winfield; John A. Worrell; Peggy A. Schuyler; Walton D. Plummer

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
754 KB
Volume
71
Category
Article
ISSN
0008-543X

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✦ Synopsis

Background. Women with proliferative breast disease (PD) have been observed to have an increased risk of breast cancer. The authors evaluated the effect of PD on breast cancer risk in a case-control study among participants of the Breast Cancer Detection Demonstration Project (BCDDP).

Methods. More than 280,000 women were screened in the BCDDP at 29 centers. Study subjects were selected from BCDDP participants who underwent biopsy that revealed benign breast tissue. There were five BCDDP centers for which histologic slides were available on more than 85% of the benign biopsy specimens. Case patients for this study were the 95 women from these five centers who had breast cancer develop during follow-up. Two matched control patients who did not have breast

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