Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk

A genetic variant in a PP2A regulatory s

A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence

✍ Alexei Vazquez; Diptee Kulkarni; Lukasz F. Grochola; Gareth L. Bond; Nicola Barn 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 818 KB

## Abstract A recent candidate gene association study identified a single nucleotide polymorphism (SNP) in the __PPP2R2B__ gene (rs319217, A/G) that manifests allelic differences in the cellular responses to treatment with chemotherapeutic agents (Vazquez et al., Nat Rev Drug Discov 2008;7:979‐87).