BRCA2 founder mutation in Slovenian breast cancer families
✍ Scribed by Krajc, Mateja; De Grève, Jacques; Goelen, Guido; Teugels, Erik
- Book ID
- 110025306
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 68 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1018-4813
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
We have screened index cases from 25 Russian breast/ovarian cancer families for germ-line mutations in all coding exons of the BRCA1 and BRCA2 genes, using multiplex heteroduplex analysis. In addition we tested 22 patients with breast cancer diagnosed before age 40 without family history and 6 patie
## Abstract Three mutations in __BRCA1__ (5382insC, C61G and 4153delA) are common in Poland and account for the majority of mutations identified to date in Polish breast and breast–ovarian cancer families. It is not known, however, to what extent these 3 founder mutations account for all of the BRC
Germline mutations of BRCA2 were examined in 20 Japanese breast cancer families without BRCA1 mutations, including one demonstrating cancer development in a male. Three different mutations, resulting in truncation of the BRCA2 protein, were detected in 3 different families. They were 9474insA (exon