Germline mutations in the BRCA1 and BRCA2 genes account for the majority of high-risk breast/ovarian cancer families, depending on the population studied. Previously, BRCA1 mutations were described in women from Western Poland. To further characterize the spectrum of BRCA1 mutations and the impact o
✦ LIBER ✦
Founder BRCA1 and BRCA2 mutations in early-onset French Canadian breast cancer cases unselected for family history
✍ Scribed by Patricia N. Tonin; Chantal Perret; Julie A. Lambert; Anne-Josée Paradis; Tania Kantemiroff; Marie-Hélène Benoît; Ginette Martin; William D. Foulkes; Parviz Ghadirian
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 59 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
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Germline mutations within the adenomatous polyposis coli (APC) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations within thi