BRCA1andBRCA2– breast cancer susceptibility genes
✍ Scribed by W. Hofmann; P. M. Schlag
- Book ID
- 106124533
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 241 KB
- Volume
- 126
- Category
- Article
- ISSN
- 1432-1335
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## Abstract The __BRCA1__ gene was identified and cloned in 1994 based its linkage to early onset breast cancer and breast‐ovarian cancer syndromes in women. While inherited mutations of BRCA1 are responsible for about 40–45% of hereditary breast cancers, these mutations account for only 2‐3% of al
Here we report the study on BRCA1 and BRCA2 mutations in 12 Thai breast and/or ovarian cancer families and 6 early-onset breast or breast/ovarian cancer cases without a family history of cancer. Five distinct rare alterations were identified in each gene: four introducing premature stop codons, one