## Abstract Index cases from a clinically relevant cohort of 102 Spanish families with at least 3 cases of breast and/or ovarian cancer (at least 1 case diagnosed before age 50) in the same lineage were screened for germline mutations in the entire coding sequence and intron boundaries of the breas
β¦ LIBER β¦
BRCA1-Related and Sporadic Ovarian Cancer in the Same Family: Implications for Genetic Testing
β Scribed by William E. Richards; Holly H. Gallion; Jason P. Schmittschmitt; Dawn V. Holladay; Simon A. Smith
- Book ID
- 112247963
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 44 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0090-8258
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The cloning of the breast and ovarian cancer susceptibility gene, BRCA1, allows direct estimation of the proportion of these cancers in the general population which can be attributed to germline mutations in this gene. We have used a combination of SSCP, heteroduplex analysis, and chemical cleavage