We report on the screening of the entire BRCA1/BRCA2 coding sequence by SSCP, PTT, and direct sequencing in 68 Italian families with recurrent breast or ovarian cancer. For each investigated proband, the probability of being carrier of a BRCA1/BRCA2 mutation was evaluated using the BRCAPRO software.
BRCA1genetic testing in 106 breast and ovarian cancer families from southern Italy (Sicily): a mutation analyses
✍ Scribed by Antonio Russo; Valentina Calò; Valentina Agnese; Loredana Bruno; Simona Corsale; Claudia Augello; Grazia Gargano; Floriana Barbera; Sandra Cascio; Chiara Intrivici; Gaetana Rinaldi; Gaspare Gulotta; Marcella Macaluso; Eva Surmacz; Antonio Giordano; Nicola Gebbia; Viviana Bazan
- Book ID
- 106377349
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 223 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Index cases from a clinically relevant cohort of 102 Spanish families with at least 3 cases of breast and/or ovarian cancer (at least 1 case diagnosed before age 50) in the same lineage were screened for germline mutations in the entire coding sequence and intron boundaries of the breas