BRCA1 mutations and clinicopathological features in a sample of Italian women with early-onset breast cancer
β Scribed by D Turchetti; L Cortesi; M Federico; C Bertoni; L Mangone; Se Ferrari; V Silingardi
- Book ID
- 117657010
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 99 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0959-8049
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Germline mutations in BRCA1 and BRCA2 account for majority of hereditary breast and ovarian cancer. The complete coding sequence analysis of both genes was carried out in 197 breast/ovarian cancer patients from high-risk families and 53 patients with sporadic breast/ovarian cancer. In summary, 59 mu
In Spain, the contribution of BRCA mutations to the population incidence of early-onset breast cancer was unknown. We carried out a mutational analysis of the BRCA1 and BRCA2 genes in 124 Spanish women diagnosed with breast cancer before the age 41 and who were not selected for a family history of t