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BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer

✍ Scribed by Judith E. Carser; Jennifer E. Quinn; Caroline O. Michie; Eamonn J. O'Brien; W. Glenn McCluggage; Perry Maxwell; Elisabeth Lamers; Tong F. Lioe; Alistair R.W. Williams; Richard D. Kennedy; Charlie Gourley; D. Paul Harkin

Book ID
113963420
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
265 KB
Volume
123
Category
Article
ISSN
0090-8258

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## Abstract Epithelial ovarian cancer (EOC) is treated mainly by platinum‐based combination chemotherapy. Chemotherapy induces apoptosis in which the Fas/Fas ligand pathway is important. Serum soluble Fas (sFas) is a biomarker of this pathway and functionally inhibits Fas‐/FasL‐mediated apoptosis.