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Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel

✍ Scribed by Oikonomopoulou, K; Li, L; Zheng, Y; Simon, I; Wolfert, R L; Valik, D; Nekulova, M; Simickova, M; Frgala, T; Diamandis, E P

Book ID
109999724
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
217 KB
Volume
99
Category
Article
ISSN
0007-0920

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## Abstract Epithelial ovarian cancer (EOC) is treated mainly by platinum‐based combination chemotherapy. Chemotherapy induces apoptosis in which the Fas/Fas ligand pathway is important. Serum soluble Fas (sFas) is a biomarker of this pathway and functionally inhibits Fas‐/FasL‐mediated apoptosis.