## Abstract Cyclin D1 plays an important role in cell cycle progression. In breast cancer, Cyclin D1 expression is deregulated by several mechanisms. We previously showed that in breast cancer cells, overexpression of BRCA1βIRIS induces Cyclin D1 overexpression and increases cell proliferation. BRC
β¦ LIBER β¦
BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells
β Scribed by Enkeleda Nakuci; Sven Mahner; James DiRenzo; Wael M. ElShamy
- Book ID
- 113955548
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 792 KB
- Volume
- 312
- Category
- Article
- ISSN
- 0014-4827
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## Abstract Cofactor of BRCA1 (COBRA1) is an integral component of the human negative elongation factor (NELF), a fourβsubunit protein complex that inhibits transcription elongation. Previous in vivo work indicates that COBRA1 and the rest of the NELF complex repress estrogenβdependent transcriptio