We analyzed germline mutations of the BRCAl gene in 20 German breast/ovarian-cancer families. BRCA I mutations cosegregating with breast-cancer susceptibility were identified in 3 of these families. All mutations were found to generate a premature stop codon leading to the synthesis of truncated BRC
BRCA1 2080insA mutation in familial breast cancer
β Scribed by Aliya S. Alansari; Mansour Al-Moundhri; Marium M. Al-Nabhani; Shoaib A. Al-Zidjali
- Publisher
- Springer US
- Year
- 2008
- Tongue
- English
- Weight
- 143 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0167-6806
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