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Brain Hypoxia and Ischemia Volume 638 || Hypoxia-Inducible Factor 1

✍ Scribed by Haddad, Gabriel G.; Yu, Shan Ping


Book ID
111912001
Publisher
Humana Press
Year
2009
Weight
170 KB
Category
Article
ISBN
1603275797

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## Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF‐1 activates the transcription of genes that increa