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Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington’s disease phenotypes in mice

✍ Scribed by Kusumika Gharami; Yuxiang Xie; Juan Ji An; Susumu Tonegawa; Baoji Xu

Book ID
111180650
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
611 KB
Volume
105
Category
Article
ISSN
0022-3042

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## Abstract Huntington's disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms and by a progressive degeneration of neurons in basal ganglia and in brain cortex. Brain‐derived neurotrophic factor (BDNF) is a pro‐survival factor for striatal neurons