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Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term potentiation in rats

✍ Scribed by Y.L Ma; H.L Wang; H.C Wu; C.L Wei; E.H.Y Lee


Book ID
117492081
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
206 KB
Volume
82
Category
Article
ISSN
0306-4522

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## Abstract The role of brain‐derived neurotrophic factor (BDNF) in recognition memory was investigated by locally infusing oligodeoxynucleotides (ODNs) into perirhinal cortex, a region of the temporal lobe essential for familiarity discrimination. Antisense but not sense BDNF ODN impaired consolid