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Interfering with perirhinal brain-derived neurotrophic factor expression impairs recognition memory in rats

✍ Scribed by Ana Seoane; Chris J. Tinsley; Malcolm W. Brown

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
370 KB
Volume
21
Category
Article
ISSN
1050-9631

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✦ Synopsis

Abstract

The role of brain‐derived neurotrophic factor (BDNF) in recognition memory was investigated by locally infusing oligodeoxynucleotides (ODNs) into perirhinal cortex, a region of the temporal lobe essential for familiarity discrimination. Antisense but not sense BDNF ODN impaired consolidation of long‐term (24h) but not shorter‐term (20min) recognition memory. © 2010 Wiley‐Liss, Inc.

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