✦ LIBER ✦

Increased expression of brain-derived neurotrophic factor but not neurotrophin-3 mRNA in rat brain after cortical impact injury

✍ Scribed by K. Yang; J.R. Perez-Polo; X.S. Mu; H.Q. Yan; J.J. Xue; Y. Iwamoto; S.J. Liu; C.E. Dixon; R.L. Hayes

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 832 KB
Volume: 44
Category: Article
ISSN: 0360-4012
DOI: 10.1002/(sici)1097-4547(19960415)44:2<157::aid-jnr8>3.0.co;2-c

No coin nor oath required. For personal study only.

✦ Synopsis

Levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) mRNA expression were measured in a rodent model of traumatic brain injury (TBI) following unilateral injury to the cerebral cortex. To obtain reliable data on the co-expression of neurotrophin genes, adjacent coronal sections from the same rat brains were hybridized in situ with BDNF and NT3 cRNA probes. BDNF mRNA increased at 1, 3, and 5 hr after unilateral cortical injury in the cortex ipsilateral to the injury site and bilaterally in the dorsal hippocampus. NT3 mRNA did not change significantly following injury. Our results suggest that TBI produces rapid increases in BDNF mRNA expression in rat brain without changes in NT3 mRNA expression, a finding which differs from studies of ischemia and seizures. It is possible that increased levels of BDNF mRNA rather than NT3 are important components of pathophysiological responses to TBI.

📜 SIMILAR VOLUMES

Expression of brain-derived neurotrophic

Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs

✍ Ou Bai; Jennifer Chlan-Fourney; Rudy Bowen; David Keegan; Xin-Min Li 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 320 KB

## Abstract Typical and atypical antipsychotic drugs, though both effective, act on different neurotransmitter receptors and are dissimilar in some clinical effects and side effects. The typical antipsychotic drug haloperidol has been shown to cause a decrease in the expression of brain‐derived neu

Regional and temporal profiles of c-fos

Regional and temporal profiles of c-fos and nerve growth factor mRNA expression in rat brain after lateral cortical impact injury

✍ K. Yang; X. S. Mu; J. J. Xue; J. R. Perez-Polo; R. L. Hayes 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 874 KB

Lesion-induced increases in NGF mRNA are thought to be mediated by c-fos gene expression. Conversely, NGF induction of c-fos expression has been reported following administration of exogenous NGF. However, the relationship between c-fos and NGF gene expression after traumatic injury to the intact br

Expression of brain-derived neurotrophic

Expression of brain-derived neurotrophic factor immunoreactivity and mRNA in the hippocampal CA1 and cortical areas after chronic ischemia in rats

✍ Tsong-Hai Lee; Jen-Tsung Yang; Hiroyuki Kato; June Hsieh Wu; Sien-Tsong Chen 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB

## Abstract We studied the expression of brain‐derived neurotrophic factor (BDNF) immunoreactivity and mRNA in the ischemia‐vulnerable cerebral hippocampal CA1 and cortical areas after permanent occlusion of bilateral internal carotid arteries. Four groups of rats were studied, including 1) young n

In situ expression of brain-derived neur

In situ expression of brain-derived neurotrophic factor or neurotrophin-3 promotes sprouting of cortical serotonergic axons following a neurotoxic lesion

✍ M.H. Grider; L.A. Mamounas; W. Le; H.D. Shine 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 530 KB

Neurotrophins promote sprouting and elongation of central nervous system (CNS) axons following injury. Consequently, it has been suggested that neurotrophins could be used to repair the CNS by inducing axonal sprouting from nearby intact axons, thereby compensating for the loss of recently injured a

Expression of nerve growth factor, brain

Expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the somatosensory cortex of the mature rat: Coexpression with high-affinity neurotrophin receptors

✍ Pitts, Andrew F.; Miller, Michael W. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 880 KB

Neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), are critical for the maintenance and plasticity of central nervous system (CNS) neurons. We tested the hypothesis that cortical neurons participate in redundant autocrine/paracrin

Brain-derived neurotrophic factor modula

Brain-derived neurotrophic factor modulates GAP-43 but not tα1 expression in injured retinal ganglion cells of adult rats

✍ A.E. Fournier; J. Beer; C.O. Arregui; C. Essagian; A.J. Aguayo; L. McKerracher 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 969 KB

The administration of neurotrophins affects neuronal survival and growth, but less is known about their ability to modify the expression of growth associated genes following injury to CNS neurons. Here we characterize the effect of brain-derived neurotrophic factor (BDNF) on mRNA levels for Ta1 a-tu