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Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat

✍ Scribed by Shigeru Genka; Joseph Deutsch; Paul L. Stahle; Umesha H. Shetty; Varghese John; Cynthia Robinson; Stanely I. Rapoport; Nigel H. Greig

Publisher
Springer
Year
1990
Tongue
English
Weight
933 KB
Volume
27
Category
Article
ISSN
0344-5704

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✍ Daniel S. Zaharko; Joseph M. Covey; Gerhardt HΓΆrpel πŸ“‚ Article πŸ“… 1984 πŸ› Springer US 🌐 English βš– 392 KB

The L1210 tumor system was used in vitro and in vivo in comparative studies with activated cyclophosphamide analogs, cyclophosphamide and phosphoramide mustard. All the above compounds gave substantial cell kills (5 logs) of L1210 in vivo at doses that were non-toxic, but slight differences were not