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Identification of new metabolites of phosphoramide and nor-nitrogen mustards and cyclophosphamide in rat urine using ion cluster techniques

โœ Scribed by Kenneth K. Chan; Suk-Chang Hong; Eric Watson; Shu-Kai Deng

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
727 KB
Volume
13
Category
Article
ISSN
1076-5174

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Identification of new metabolites of ifo
Identification of new metabolites of ifosfamide in rat urine using ion cluster technique
โœ Jeff J.-H. Wang; Kenneth K. Chan ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 875 KB

Metabolism of the anticancer drug ifosfamide was investigated in SpragueDawley rats. Along with four known metabolites, namely p-dechloroethylifosfamide, M-dechloroethylifosfamide, alcoifosfamide and isophosphoramide mustard, four new urinary metabolites were identified utilizing combined techniques