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Both NUP98/TOP1 and TOP1/NUP98 transcripts are detected in a de novo AML with t(11;20)(p15;q11)

✍ Scribed by Satsuki Iwase; Nobutake Akiyama; Tetsuaki Sekikawa; Shinobu Saito; Yasuhiro Arakawa; Junko Horiguchi-Yamada; Hisashi Yamada

Book ID: 102218278
Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 302 KB
Volume: 38
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.10239

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✦ Synopsis

Abstract

The NUP98 gene is involved in several chromosomal abnormalities associated with acute leukemia. The recurrent t(11;20)(p15;q11) chromosomal translocation results in generation of the NUP98/TOP1 chimeric gene. This abnormality has been observed primarily in therapy‐related leukemias, and TOP1/NUP98 transcripts have not been demonstrated. We describe a case of de novo acute myeloid leukemia with t(11;20)(p15;q11), with no known history of exposure to chemicals. The translocation occurred in intron 13 of NUP98 and intron 7 of TOP1, as in the three previously reported cases. The breakpoint in NUP98 was exactly the same as that found in a previously reported case. In addition, a reciprocal TOP1/NUP98 transcript was detected for the first time in our patient. © 2003 Wiley‐Liss, Inc.

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