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Bone marrow transplantation with high-dose cytosine arabinoside

✍ Scribed by Herzig, R. H. ;Lazarus, H. M. ;Graham-Pole, J. ;Gross, S. ;Coccia, P. ;Gordon, E. M. ;Strandjord, S. ;Phillips, G. L. ;Herzig, G. P.

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
243 KB
Volume
10
Category
Article
ISSN
0098-1532

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✦ Synopsis

Eleven patients received allogeneic bone marrow from all HCA-identical sibling for the treatment of acute leukemia. The preparative regiment included high-dose cytosine arabinoside (Ara-C), 3 g/m2q 12 h for 12 doses, and lo00 rad singlefraction total body irradiation (5 patients) or 1200 rad fractionated total body irradiation (6 patients). The 5 patients receiving the lo00 rad single-fraction regimen were transplanted in relapse, while the 6 patients receiving the 1200 rad fractionated program were transplanted during remission. Both regimens were well-tolerated, but the single-dose radiation regimen was associated with more severe skin problems. Bone marrow engraftment was documented in 10 of 10 evaluable patients, occurring 2-3 weeks after marrow infusion. No recurrences have been observed during the brief follow-up time.

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