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BMP-7-Induced Cell Cycle Arrest of Anaplastic Thyroid Carcinoma Cells via p21CIP1 and p27KIP1

✍ Scribed by Åsa Franzén; Nils-Erik Heldin

Book ID: 115588275
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 305 KB
Volume: 285
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.2001.5212

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## Transforming growth factor-␤1 (TGF-␤) inhibits cell-cycle progression of many types of cells by arresting them in G 1 /S phase through inhibition of the active cyclin-Cdk complexes that lead to inhibition of Rb phosphorylation. In gastriccancer cells, SNU16, TGF-␤ treatment induced enhanced exp