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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

✍ Scribed by Leung, Carly; Lingbeek, Merel; Shakhova, Olga; Liu, James; Tanger, Ellen; Saremaslani, Parvin; van Lohuizen, Maarten; Marino, Silvia


Book ID
109892758
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
373 KB
Volume
428
Category
Article
ISSN
0028-0836

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## Abstract The protein products of the __Dickkopf__ (__DKK__) genes are antagonists of Wnt glycoproteins, which participate in tumor development and progression by binding to frizzled receptors. In this study, the expression of DKK‐1 was analyzed in a panel of 43 human cultured carcinoma cell line