The biochemical defect in Bloom's syndrome (BS) remains unknown, but two characteristic features of BS cells point to a disturbance of DNA replication, namely, an excessive number of sister-chromatid exchanges (SCEs) in bromodeoxyuridine (BrdU)-substituted cells and an abnormally slow rate of replic
โฆ LIBER โฆ
Bloom's syndrome
โ Scribed by Frederic N. Silverman
- Book ID
- 118974392
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- English
- Weight
- 58 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0037-198X
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This article focusses upon defining those factors which may contributc to the pathogenesis of cancer. The molecular basis of tumour etiology is discussed with reference to cancer predisposing syndromes, and in particular to the human inherited disease, Bloom's syndrome. In Bloom's syndrome, patients