✦ LIBER ✦

Cancer predisposition in bloom's syndrome

✍ Scribed by Neil F. Sullivan; Anne E. Willis

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 531 KB
Volume: 14
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950140508

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✦ Synopsis

This article focusses upon defining those factors which may contributc to the pathogenesis of cancer. The molecular basis of tumour etiology is discussed with reference to cancer predisposing syndromes, and in particular to the human inherited disease, Bloom's syndrome. In Bloom's syndrome, patients are predisposed to a wide variety of malignant disease. We propose a model in which overexpression of the ubiquitous c-mye proto-oncogene contributes to this process.

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