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Blood lymphocyte characteristics as predictors of prognosis in chronic lymphocytic leukemia of B-cell type

✍ Scribed by E. Kimby; H. Mellstedt; B. Nilsson; M. Björkholm; G. Holm; C. Lindemalm; B. Tribukait

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
479 KB
Volume
6
Category
Article
ISSN
0278-0232

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✦ Synopsis

The prognostic information of blood lymphocyte characteristics and clinical findings was assessed in 62 patients with chronic lymphocytic leukemia of B cell type. Bivariate and multivariate survival analyses were performed using age, Rai stage, surface membrane immunoglobulin (smIg,) isotype pattern of the leukemic clone, total lymphocyte counts, numbers of proliferating lymphocytes and T cell subpopulations. Rai stages 111 and IV, high numbers of blood lymphocytes in S-phase (S') and smp isotype were found to be partly independent factors predicting short therapy-free survival. Patients with a smp' leukemic cell clone had a shorter therapy-free and total survival compared to those with smp+/S+ and smS+ leukemic cells. Moreoever, patients with high numbers ofblood S+ lymphocytes had a shorter therapy-free and total survival compared to those with few S+ cells. These prognostic variables were valid also in patients with a low tumour burden (Rai stages 0, I and 11) and may thus be of clinical importance as a guideline for therapeutic intervention.

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