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Blood cells of Drosophila: cell lineages and role in host defence

✍ Scribed by Marie Meister

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
159 KB
Volume
16
Category
Article
ISSN
0952-7915

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✦ Synopsis

Drosophila haemopoiesis gives rise to three independent cell lineages: plasmatocytes, crystal cells and lamellocytes. The regulation of Drosophila stem cell proliferation and lineage specification involves transactivators and signalling pathways, many of which have mammalian counterparts that control haemopoietic processes. Drosophila plasmatocytes are professional phagocytes that resemble the monocyte/ macrophage lineage, crystal cells play a critical role in defence-related melanisation, and lamellocytes encapsulate large invaders. Crystal cells and lamellocytes have no clear mammalian homologues. Research into the molecular mechanisms that underlie the various immune functions of Drosophila blood cells, such as non-self recognition, is now taking wing.

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