Role of the red blood cell in drug metabolism
โ Scribed by Paul A. Cossum
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 977 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
When rats were exposed to 2 mg I-' ( -640 ppm) of carbon disulfide (CS,) for 4 h, the concentration of free CS, in the red blood cells (RBCs) approached a plateau within 2 h. Free CS, in plasma reached a steady state concentration within 15 min of exposure. More than 90% of the free CS, in blood was
## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t
The effect on red blood cell metabolism of a series of substituted 1,4-naphthoquinones has been investigated. 2-Methoxy-1,4-naphthoquinone was found to be a potent oxidative compound, generating hydrogen peroxide in erythrocytes and causing both methemoglobin formation and glutathione depletion in t