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Block of a glioma cell line in S by interferon

✍ Scribed by D. Lundblad; E. Lundgren

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
445 KB
Volume
27
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The human glioma cell line U‐251 MG, with a well‐characterized defect in growth control, was sensitive to the antiproliferative effects of human (fibroblast) interferon (IFN). IFN inhibited exponentially growing cells by increasing the number of cells in the S stage of the cell cycle. At the same time the number of cells in G~0~/G~1~ diminished. The rate of thymidine incorporation was decreased during the first cell cycle, with no prolongation of S. However, in synchronized cultures, the wave of cells with a S‐phase content did not decrease over a time period several hours longer than the length of S measured by pulse labelling. Thus we conclude that, at a sufficient dose, the cells were unable to accomplish cell division as they prematurely stopped synthesizing DNA.

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