𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Blastic crisis in chronic granulocytic leukemia: Experience in 39 patients

✍ Scribed by Carlos S. Vallejos; José M. Trujillo; Ann Cork; Gerald P. Bodey; Kenneth B. McCredie; Emil J Freireich

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
560 KB
Volume
34
Category
Article
ISSN
0008-543X

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✦ Synopsis

In a n attempt to prolong survival, a group of 39 adult patients with chronic granulocytic leukemia in acute transformation was treated with intensive chemotherapy regimens which included the use of single agents o r drug combinations. An over-all remission rate of 28% was obtained, with only 10% of the patients achieving complete remission. The cytogenetic profiles obtained during the acute phase of the disease were correlated with the clinical findings and the response t o therapy. The results presented in this report indicate that, even with the use of modern therapeutic drugs, once chronic granulocytic leukemia enters a phase of acute transformation, the prognosis is equally poor for both Ph1 negative and Phl positive patients.

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