Autopsy study of blast crisis in patients with chronic granulocytic leukemia, Hiroshima and Nagasaki, 1949–1969

✍ Scribed by Paul I. Liu; Toranosuke Ishimaru; Douglas H. McGregor

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 453 KB
• Volume: 33
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197404)33:4<1062::aid-cncr2820330425>3.0.co;2-k

✦ Synopsis

This report examines the relation of blast crisis to whole body radiation a t the time of the atomic b o m b (ATB), and describes the autopsy findings in 23 cases of CGL with terminal blast crisis f o u n d among 101 CGL cases autopsied in Hiroshima and Nagasaki, Japan, d u r i n g the period 1949-1969. No evidence was found t h a t blast crisis was more frequent in A-bomb survivors w h o had been exposed t o ionizing radiation ATB t h a n i n non-exposed persons. Conseqpently, in this regard, as i n other parameters reported previously, postirradiation leukemia is shown t o be indistinguishable from "spontaneous" leukemia. The occurrence of blast crisis in this series is evaluated i n relation to prevalence, year of death, age at onset and death, d u r a t i o n of disease, sex, hemorrhagic manifestations, and leukemic infiltration in various organs.