On the entropy of protein folding
โ
George I. Makhatadze; Peter L. Privalov
๐
Article
๐
2008
๐
Cold Spring Harbor Laboratory Press
๐
English
โ 484 KB
## Abstract The failure to appreciate that the hydration of polar groups is a major contribution to the entropy of protein unfolding has led to considerable underestimates for the loss of configurational freedom when a protein chain folds.