THEORY OF PROTEIN FOLDING: The Energy Landscape Perspective
✍ Scribed by Onuchic, José Nelson; Luthey-Schulten, Zaida; Wolynes, Peter G.
- Book ID
- 111901338
- Publisher
- Annual Reviews
- Year
- 1997
- Tongue
- English
- Weight
- 524 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0066-426X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The Notch ankyrin domain is a repeat protein whose folding has been characterized through equilibrium and kinetic measurements. In previous work, equilibrium folding free energies of truncated constructs were used to generate an experimentally determined folding energy landscape (Mello
We use two simple models and the energy landscape perspective to study protein folding kinetics. A major challenge has been to use the landscape perspective to interpret experimental data, which requires ensemble averaging over the microscopic trajectories usually observed in such models. Here, beca
We have calculated the free energy of a spherical model of a protein or part of a protein generated in the way of protein folding. Two spherical models are examined; one is a homogeneous model consisting of only one residue type-hydrophobic. The other is a heterogeneous model consisting of two resid